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  1. We conducted a correlative study for E2399, a function preservation trial for resectable locally advanced oropharynx and larynx cancer, to prospectively assess effects of chemoradiation (CCR) on quality of lif...

    Authors: Anthony Cmelak, Mary S. Dietrich, Shuli Li, Sheila Ridner, Arlene Forastiere, Barbara A. Burtness, David Cella and Barbara A. Murphy
    Citation: Cancers of the Head & Neck 2020 5:12
  2. Human papillomavirus (HPV) associated head and neck squamous cell carcinoma (HNSCC) has a better prognosis than HNSCC due to other risk factors. However, there is significant heterogeneity within HPV-associate...

    Authors: Suchin Khanna, Sarah Palackdharry, Logan Roof, Christina A. Wicker, Jonathan Mark, Zheng Zhu, Roman Jandorav, Alfredo Molinolo, Vinita Takiar and Trisha M. Wise-Draper
    Citation: Cancers of the Head & Neck 2020 5:11
  3. Cancer burden in sub-Saharan Africa is on the rise with one-third of cancers estimated to be caused by infectious agents. Head and neck squamous cell cancer (HNSCC) is the sixth most common malignancy in sub-S...

    Authors: Fiona Kabagenyi, Jeff Otiti, Justine Namwagala, Adriane Kamulegeya and Sam Kalungi
    Citation: Cancers of the Head & Neck 2020 5:10
  4. Comprehensive molecular characterization of head and neck squamous cell carcinoma (HNSCC) has led to the identification of distinct molecular subgroups with fundamental differences in biological properties and...

    Authors: Ingeborg Tinhofer, Diana Braunholz and Konrad Klinghammer
    Citation: Cancers of the Head & Neck 2020 5:9
  5. The latency of the swallowing reflex is an important factor causing dysphagia in head and neck cancer patients. Although there are many reports comparing voluntary swallowing function before and after treatmen...

    Authors: Akira Ohkoshi, Kengo Kato, Takenori Ogawa, Ayako Nakanome, Ryo Ishii and Yukio Katori
    Citation: Cancers of the Head & Neck 2020 5:8
  6. Recent advancements in computational power, machine learning, and artificial intelligence technology have enabled automated evaluation of medical images to generate quantitative diagnostic and prognostic bioma...

    Authors: Stefan P. Haider, Barbara Burtness, Wendell G. Yarbrough and Seyedmehdi Payabvash
    Citation: Cancers of the Head & Neck 2020 5:6
  7. As the number of indicated malignancies for which immune checkpoint inhibitor therapy such as pembrolizumab grows the descriptions of associated immune-related adverse events (irAEs) increases as well. On rare...

    Authors: James Kalmuk, Jon Puchalla, Gong Feng, Anshu Giri and John Kaczmar
    Citation: Cancers of the Head & Neck 2020 5:3
  8. For many years, head and neck squamous cell carcinoma (HNSCC) has been considered as a single entity. However, in the last decades HNSCC complexity and heterogeneity have been recognized. In parallel, high-thr...

    Authors: Mara S. Serafini, Laura Lopez-Perez, Giuseppe Fico, Lisa Licitra, Loris De Cecco and Carlo Resteghini
    Citation: Cancers of the Head & Neck 2020 5:2
  9. Although there have been dramatic improvements in radiotherapy for head and neck squamous cell carcinoma (HNSCC), including robust intensity modulation and daily image guidance, these advances are not able to ...

    Authors: Howard E. Morgan and David J. Sher
    Citation: Cancers of the Head & Neck 2020 5:1
  10. The genomic landscape of head and neck cancer has been reported through The Cancer Genome Atlas project. We attempt to determine if high-risk human papillomavirus (HPV) or frequently mutated genes are correlat...

    Authors: Neil Mundi, Stephenie D. Prokopec, Farhad Ghasemi, Andrew Warner, Krupal Patel, Danielle MacNeil, Christopher Howlett, William Stecho, Paul Plantinga, Nicole Pinto, Kara M. Ruicci, Mohammed Imran Khan, Myung Woul Han, John Yoo, Kevin Fung, Axel Sahovaler…
    Citation: Cancers of the Head & Neck 2019 4:5
  11. The optimal treatment for regional lymphatic recurrences from head and neck cancer has not been fully established. In order to explore the therapeutic benefit of surgical resection and adjuvant brachytherapy, ...

    Authors: Nayel Khan, Mark Clemens, Jun Liu, Adam S. Garden, Anne Lawyer, Randal Weber, G. Brandon Gunn, William H. Morrison and Michael E. Kupferman
    Citation: Cancers of the Head & Neck 2019 4:4
  12. Compared to HPV-negative head and neck squamous cell carcinomas (HNSCCs), HPV-positive HNSCCs are associated with a favorable prognosis in part due to their improved treatment sensitivity. Inactivating mutatio...

    Authors: Cassie Pan, Said Izreig, Wendell G. Yarbrough and Natalia Issaeva
    Citation: Cancers of the Head & Neck 2019 4:3
  13. Patients with head and neck cancer (HNC) experience significant physical and psychological distress, which have a negative impact on their quality of life (QOL). Few strategies have been studied to help improv...

    Authors: Jordan J. Senchak, Carolyn Y. Fang and Jessica R. Bauman
    Citation: Cancers of the Head & Neck 2019 4:2
  14. Human papillomavirus-associated oropharyngeal cancer (HPV-OSCC) is rapidly increasing in incidence and has unique epidemiologic, molecular, and biologic characteristics. Standard combined modality therapies fo...

    Authors: Panagiota Economopoulou and Amanda Psyrri
    Citation: Cancers of the Head & Neck 2019 4:1
  15. Understanding of oropharyngeal squamous cell carcinoma has significantly progressed over the last decades, and the concept that this disease can be subdivided into two distinct entities based on human papillom...

    Authors: Cassie Pan, Natalia Issaeva and Wendell G. Yarbrough
    Citation: Cancers of the Head & Neck 2018 3:12
  16. Increased treatment package time is an independent poor prognostic factor for outcomes in head and neck squamous cell carcinoma (HNSCC). Similarly the timeliness of treatment initiation is a risk factor for di...

    Authors: Muhammad M. Fareed and Thomas J. Galloway
    Citation: Cancers of the Head & Neck 2018 3:11
  17. Information on patients with differentiated thyroid carcinoma in South Africa is limited. The objective of this study was to review demographics and tumour characteristics in a cohort of patients with differen...

    Authors: B. Robertson, M. Parker, L. Shepherd, E. Panieri, L. Cairncross, F. Malherbe, IL. Ross, F. Omar and A. Hunter
    Citation: Cancers of the Head & Neck 2018 3:10
  18. Despite improvements in diagnosis and patient management, survival and prognostic factors of patients with oral squamous cell carcinoma (OSCC) remains largely unknown in most of Sub Saharan Africa.

    Authors: Juliet Asio, Adriane Kamulegeya and Cecily Banura
    Citation: Cancers of the Head & Neck 2018 3:9
  19. HPV related OPSCC has a distinct behavior and improved outcome. As immunotherapy has recently evolved into a new standard for advanced (SCCHN), trials for high-risk SCCHN have trended to encompass both HPV rel...

    Authors: Nabil F Saba, Shuli Li, Zain A Hussain, Rathan Subramanian, Joseph A Califano and Christine H Chung
    Citation: Cancers of the Head & Neck 2018 3:8
  20. Airline crew are exposed to ionizing radiation as part of their occupation and have a documented increased risk of melanoma and cataracts. However, whether their occupation predisposes them to an increased ris...

    Authors: George S. Liu, Austin Cook, Michael Richardson, Daniel Vail, F. Christopher Holsinger and Ingrid Oakley-Girvan
    Citation: Cancers of the Head & Neck 2018 3:7
  21. Significant weight loss and malnutrition are common in patients with head and neck cancer, despite advances in treatment and development of evidenced-based guidelines. The aim of this study was to assess adher...

    Authors: Sophie Hofto, Jessica Abbott, James E. Jackson and Elisabeth Isenring
    Citation: Cancers of the Head & Neck 2018 3:6
  22. Extracapsular extension (ECE) is a well-established prognostic feature in squamous cell cancers of the head and neck. Although some extrapolate data from mucosal head and neck cancer to include ECE as a high-r...

    Authors: Shayan Cheraghlou, Phoebe K. Yu, Michael D. Otremba, Saral Mehra, Wendell G. Yarbrough and Benjamin L. Judson
    Citation: Cancers of the Head & Neck 2018 3:5
  23. Human papilloma virus (HPV)-associated head and neck cancer is now recognized as a distinct clinical entity from HPV-negative tumors, which are primarily associated with tobacco and alcohol exposure.Little is...

    Authors: Hong Li, Henry S. Park, Heather A. Osborn and Benjamin L. Judson
    Citation: Cancers of the Head & Neck 2018 3:4
  24. Circulating interleukin-6 (IL-6) improves outcome prediction for second primary cancer (SPC) in head and neck cancer (HNC) patients. This study aimed to identify factors associated with IL-6 serum levels in HN...

    Authors: Sylvine Carrondo Cottin, StƩphane Turcotte, Pierre Douville, FranƧois Meyer and Isabelle Bairati
    Citation: Cancers of the Head & Neck 2018 3:1
  25. Synchronous squamous cell carcinoma of the head and neck (HNSCC) and non-Hodgkinā€™s lymphoma is a rare clinical scenario. It is unknown whether the R-CHOP chemotherapy for lymphoma would also be active against ...

    Authors: Ting Martin Ma, Hyunseok Kang, Steven P. Rowe and Ana P. Kiess
    Citation: Cancers of the Head & Neck 2018 3:2
  26. The present study evaluated clinical outcomes for patients with head and neck squamous cell carcinoma presenting with N3 nodal disease.

    Authors: Matthew E. Witek, Aaron M. Wieland, Shuai Chen, Tabassum A. Kennedy, Craig R. Hullett, Evan Liang, Gregory K. Hartig, Randy J. Kimple and Paul M. Harari
    Citation: Cancers of the Head & Neck 2017 2:8
  27. Treatment modalities of head and neck squamous cell cancer include surgery, radiation, chemotherapy, targeted agents and immune checkpoint inhibition. Treatment is often toxic and can affect long-term function...

    Authors: Nnamdi Eze, Ying-Chun Lo and Barbara Burtness
    Citation: Cancers of the Head & Neck 2017 2:6
  28. Transoral endoscopic head and neck surgery (eHNS), including transoral laser microsurgery (TLM) and transoral robotic surgery (TORS), provides access to subsites in the head and neck that have traditionally be...

    Authors: David W. Schoppy, Michael E. Kupferman, Amy C. Hessel, Diana M. Bell, Elizabeth M. Garland, Edward J. Damrose and F. Christopher Holsinger
    Citation: Cancers of the Head & Neck 2017 2:5
  29. To find out how chemotherapy given prior to concurrent chemoradiotherapy compares with concurrent chemoradiation alone in the treatment of locally advanced nasopharyngeal cancer.

    Authors: Joel Yarney, Naa A. Aryeetey, Alice Mensah, Emmanuel D. Kitcher, Verna Vanderpuye, Charles Aidoo and Kenneth Baidoo
    Citation: Cancers of the Head & Neck 2017 2:4
  30. Small cell carcinoma (SCC) is a rare variant of head and neck cancer characterized by a high-grade neuroendocrine cancer with similar features to small cell lung carcinoma (SCLC). Human papillomavirus (HPV) is...

    Authors: Marcelo Bonomi, Tamjeed Ahmed, David Warner, Joshua Waltonen, Christopher Sullivan, Mercedes Porosnicu, Katharine Batt, Jimmy Ruiz and James Cappellari
    Citation: Cancers of the Head & Neck 2017 2:3
  31. Locally advanced (stage III or IV) squamous cell carcinoma of the head and neck (SCCHN) often requires multimodal treatment, consisting of a combination of surgery, radiation, and/or systemic therapy, namely c...

    Authors: Paolo Bossi and Francesca Platini
    Citation: Cancers of the Head & Neck 2017 2:2
  32. Thyroid cancer incidence is rapidly increasing due to increased detection and diagnosis of indolent thyroid cancer, i.e. cancer that is likely to be clinically insignificant. Clinical, radiologic, and patholog...

    Authors: Lewis D. Hahn, Christian A. Kunder, Michelle M. Chen, Lisa A. Orloff and Terry S. Desser
    Citation: Cancers of the Head & Neck 2017 2:1
  33. Oropharyngeal cancer is frequently associated with human papilloma virus, that also represents a strong prognostic factor. Local relaps and treatment-related complications are frequent, whereas distant metasta...

    Authors: Daris Ferrari, Carla CodecĆ , Giulia Viale, Barbara Bocci, Francesca Broggio, Francesca Crepaldi, Martina Violati, Andrea Luciani, Dario Bauer, Laura Moneghini, Gaetano Bulfamante and Paolo Foa
    Citation: Cancers of the Head & Neck 2016 1:16
  34. For complex reconstruction of osseous defects of the head and neck, three-dimensional (3D) computer planning has been available for over 20 years. However, despite its availability and recent refinements, it i...

    Authors: Diana N. Kirke, Randall P. Owen, Vincent Carrao, Brett A Miles and Jason I. Kass
    Citation: Cancers of the Head & Neck 2016 1:17
  35. Venous thromboembolism (VTE) is a major cause of perioperative morbidity and mortality. Historically, otolaryngology surgery has been seen as very low risk of VTE, given the relatively short procedures and hea...

    Authors: Faisal I. Ahmad and Daniel R. Clayburgh
    Citation: Cancers of the Head & Neck 2016 1:13
  36. Therapeutic improvements and epidemiologic changes in head and neck cancer (HNC) over the last three decades have led to increased numbers of survivors, resulting in greater need for continuing management of o...

    Authors: Firoozeh Samim, Joel B. Epstein, Zachary S. Zumsteg, Allen S. Ho and Andrei Barasch
    Citation: Cancers of the Head & Neck 2016 1:14
  37. Head and neck squamous cell carcinoma (HNSCC) represents a model of escape from anti-tumor immunity. The high frequency of p53 tumor suppressor loss in HNSCC leads to genomic instability and immune stimulation...

    Authors: Ruth J. Davis, Robert L. Ferris and Nicole C. Schmitt
    Citation: Cancers of the Head & Neck 2016 1:12
  38. Germline CYLD mutation is associated with the development of a rare inheritable syndrome, called the CYLD cutaneous syndrome. Patients with this syndrome are distinctly presented with multiple tumors in the head ...

    Authors: Krista Roberta Verhoeft, Hoi Lam Ngan and Vivian Wai Yan Lui
    Citation: Cancers of the Head & Neck 2016 1:10
  39. Treatment of locally advanced squamous cell carcinomas of the head and neck (SCCHN) remains unsatisfactory. Although the addition of concurrent radiochemotherapy (RCT) or the combination of radiotherapy with b...

    Authors: Ingeborg Tinhofer, Volker Budach, Korinna Jƶhrens and Ulrich Keilholz
    Citation: Cancers of the Head & Neck 2016 1:8
  40. The purpose of this study was to identify preoperative patient characteristics associated with the incidence of positive surgical margins or lymph node extracapsular extension (ECE), which necessitate adjuvant...

    Authors: Harry E. Subramanian, Henry S. Park, Andrea Barbieri, Amit Mahajan, Benjamin L. Judson, Saral Mehra, Wendell G. Yarbrough, Barbara A. Burtness and Zain A. Husain
    Citation: Cancers of the Head & Neck 2016 1:7