Time abides long enough for those who make use of it

Table 2 Growth rate analyses between diagnostic imaging scan and radiation treatment planning scan

	Institution	Era	N	Patients	Median scan interval	Growth rate	Survival
Waaijer [31]	UMC Utrecht	1996–2001	13	OPC	37 days	TVD: 96 days
Waaijer [31]	UMC Utrecht	1996–2001	13	OPC	37 days	Range 21–256
Jensen [30]	Aarhus	2000–2005	61	Pharynx/Larynx/Oral Cavity	28 days	TVD: 99 days
Jensen [30]	Aarhus	2000–2005	61	Pharynx/Larynx/Oral Cavity	28 days	Range 15 to > 234
van Bockel [32]	UMC Utrecht	1996–2009	131	Larynx	26 days	HR for growth rate above median: 2.35	HR 1.93 (1.15–3.24) Dichotomous: −0.3ln (cc/day)
Murphy [29]	FCCC	2007–2014	85	OPC	35 days	TVD: 94 days	HR 1.94 (1.25–3.00)
Murphy [29]	FCCC	2007–2014	85	OPC	35 days	TSGR: 0.74%/day	Continuous
Perni [33]	MDACC	2004–2008	101	OPC	27 days	TVD: 112 days	HR 17.2 (5–75)
Perni [33]	MDACC	2004–2008	101	OPC	27 days	TGV: 0.65%/day	Dichotomous: 1%/day

OPC = oropharynx cancer, TVD = tumor volume doubling time, TSGR = tumor specific growth rate, TGV = volumetric tumor growth velocity. TSGR and TGV are functionally the same
*In 2 analyses the impact of survival is not available. In the 3 analyses for which survival is reported this is from a multivariate analysis controlling for other risk factors potentially associated with survival

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