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Table 2 Growth rate analyses between diagnostic imaging scan and radiation treatment planning scan

From: Time abides long enough for those who make use of it

  Institution Era N Patients Median scan interval Growth rate Survival
Waaijer [31] UMC Utrecht 1996–2001 13 OPC 37 days TVD: 96 days  
Range 21–256
Jensen [30] Aarhus 2000–2005 61 Pharynx/Larynx/Oral Cavity 28 days TVD: 99 days  
Range 15 to > 234
van Bockel [32] UMC Utrecht 1996–2009 131 Larynx 26 days HR for growth rate above median: 2.35 HR 1.93 (1.15–3.24) Dichotomous: −0.3ln (cc/day)
Murphy [29] FCCC 2007–2014 85 OPC 35 days TVD: 94 days HR 1.94 (1.25–3.00)
TSGR: 0.74%/day Continuous
Perni [33] MDACC 2004–2008 101 OPC 27 days TVD: 112 days HR 17.2 (5–75)
TGV: 0.65%/day Dichotomous: 1%/day
  1. OPC = oropharynx cancer, TVD = tumor volume doubling time, TSGR = tumor specific growth rate, TGV = volumetric tumor growth velocity. TSGR and TGV are functionally the same
  2. *In 2 analyses the impact of survival is not available. In the 3 analyses for which survival is reported this is from a multivariate analysis controlling for other risk factors potentially associated with survival