Optimal use of lenvatinib in the treatment of advanced thyroid cancer

Table 3 Cases of hemorrhage

Patient	Subtype	Type of hemorrhage	Outcome	Time to onset (days)	Dose (mg)	Region infiltrated			Tracheotomy	Fistula formation	Small hemorrhage as a predictor	External radiation
Patient	Subtype	Type of hemorrhage	Outcome	Time to onset (days)	Dose (mg)	Carotid artery	Skin	Trachea	Tracheotomy	Fistula formation	Small hemorrhage as a predictor	External radiation
1	DTC	Arterial hemorrhage	Death	37	24	○	○	○	N	Y (skin, trachea, esophagus)	Y (same day)	60 Gy
2	ATC	Arterial hemorrhage	Death	29	20	○	△	△	Y	N	N	N
3	ATC	Arterial hemorrhage	Sequelae	8	24	×	○	○	N	Y (skin)	N	60 Gy
4	ATC	Tumor hemorrhage	Recovered	38	20	○	○	○	N	Y (skin infiltration)	Y (same day), N	60 Gy
4	ATC	Arterial hemorrhage	Recovered	65	-	○	○	○	N	Y (skin infiltration)	Y (same day), N	60 Gy
5	ATC	Tumor hemorrhage	Did not recover	20	10	○	○	○	N	Y (skin)	N	40 Gy
6	ATC	Wound hemorrhage	Recovered	19	24	△	×	△	Y	Y (skin)	Y (same day)	N
7	DTC	Venous hemorrhage	Death	106	14	○	○	×	N	Y (skin)	Y (previous day)	N
8	ATC	Arterial hemorrhage	Death	25	24	○	○	○	Y	Y (skin)	Y (5 days before the event previous day)	N
9	DTC	Arterial hemorrhage	Recovered	135	8	△	○	×	N	Y (skin)	N	N
10	ATC	Hemorrhage	Death	153	10	△	×	○	Y	N	Y (a few days before the event	N
11	DTC	Arterial hemorrhage	Death	23	10	○	×	×	Y	N	N	60 Gy
12	DTC	Arterial rupture	Death	209	14	×	×	×	N	Y (trachea, esophagus)	N	60 Gy
13	DTC	Arterial hemorrhage	Death	237	14	△	Unknown	×	N	Y (skin)	N	60 Gy
14	ATC	Arterial hemorrhage	Did not recover	51	24	○	○	○	N	Y (esophagus)	Y (previous day)	N

ATC anaplastic thyroid cancer; DTC differentiated thyroid cancer; N no; Y, yes
○The tumor had infiltrated tissues or infiltration was suspected
△The tumor was located next to tissues
×The tumor had not infiltrated tissues and was not located next to tissues

ISSN: 2059-7347