Table 3 Currently accruing or upcoming clinical trials in anatomy-adapted adaptive radiotherapy (A-ART)

Evaluation of the Automatic Deformable Recontouring on the Daily MVCT for Head and Neck Cancer Adaptive Radiotherapy (GIRAFE) [45, 60]

Laprie Anne

(Institut Universitaire Du Cancer Toulouse, Oncopole, France)

Prospective phase II trial evaluating the accuracy of deformable image registration on daily MV-CTs. Deformable image registration will be compared to manual recontouring on weeks 3, 4, 5, and 6.

Primary Outcome: Dice similarity coefficient

Implication: if deformable image registration is reliable, may help streamline A-ART and assist with identification of those who would benefit

T3–4 and/or node > 2 cm HNSCC receiving definitive RT

48

Not yet recruiting (as of July 25, 2019)

A Prospective Non-Inferiority Trial of the Use of Adaptive Radiotherapy for Head and Neck Cancer Undergoing Radiation Therapy [45]

Jillian Tsai, MD

(Memorial Sloan Kettering Cancer Center)

Prospective trial comparing LRFS in those receiving ART to historical controls with the intent of assessing non-inferiority

Primary Outcome: LRFS at 2 years

HNSCC receiving definitive RT

65 [61]

Active, not recruiting (as of May 27, 2019)

MRI-guided Adaptive RadioTHerapy for reducing xerostomiA in Head and Neck Cancer (MARTHA-trial) [50]

Panagiotis Balermpas, MD

(University Hospital Zurich)

Prospective trial of MRI-guided IGRT with daily MRI imaging and weekly plan adaptation, with the objective of evaluating xerostomia by LENT-SOMA and salivary flow measurements at baseline, 6, 12, and 24 months

Primary Outcome: 12 month grade 2 or worse xerostomia

Stages II-IVb HNSCC receiving definitive RT

44

Not yet recruiting