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Table 1 Patient Characteristics

From: The role of salvage surgery with interstitial brachytherapy for the Management of Regionally Recurrent Head and Neck Cancers

Variable

Frequency (%)

Age median [range], years

57.6 [28.6–84.0]

Gender

 Male

39 (77%)

 Female

12 (23%)

Significant history of tobacco use

 Yes

34 (67%)

 No

17 (33%)

Significant history of alcohol use

 Yes

13 (25%)

 No

38 (75%)

Primary Site

 

 Oropharynx

22 (43%)

 Unknown Primary

7 (13%)

 Hypopharynx

4 (8%)

 Skin

4 (8%)

 Larynx

4 (8%)

 Major Salivary Gland

4 (8%)

 Sinonasal

3 (6%)

 Nasopharynx

2 (4%)

 Oral cavity

1 (2%)

Pathology

 Squamous cell carcinoma

47 (92%)

 Acinic cell carcinoma

1 (2%)

 Adenoid cystic carcinoma

1 (2%)

 Myoepithelial carcinoma

1 (2%)

 Salivary duct carcinoma

1 (2%)

T stage

 2

2 (4%)

 3

7 (14%)

 4A

36 (70%)

 4B

4 (8%)

 4C

2 (4%)

Prior neck dissection

 Yes

27 (53%)

 No

24 (47%)

Chemotherapy (initial treatment)

 Yes

36 (71%)

 No

15 (29%)

Median initial XRT dose [range], Gy

66.0 [50–72]

Type of salvage Neck Dissection

 Modified Radical Neck Dissection

36 (71%)

 Radical Neck Dissection

15 (29%)

Interstitial Brachytherapy

 Median dose [range], Gy

60 [40–62]

 Average dose ± std., Gy

57.7 ± 4.8

 Average duration [range], d

5 [3–6]

 Average dose rate [range], cGy/h

60 (36–90)

  1. XRT, radiation therapy; Gy, Gray; mo, months;
  2. std., standard deviation; d, days; cGy/h, centiGray per hour;† mean time to neck recurrence is calculated for 14 patients who had local regional recurrence