Skip to main content

Table 1 Clinical characteristics of TCGA HPV(−) cohort by NSD1 mutation status

From: NSD1 mutations by HPV status in head and neck cancer: differences in survival and response to DNA-damaging agents

  Mutated NSD1, n = 60 Wild-type NSD1, n = 397 p-value*
n % n %  
Avg. age at diagnosis (years) 60.0   61.6   0.25
Sex      0.16
 Female 13 21.7 121 30.5  
 Male 47 78.3 276 69.5  
Race      0.59
 American Indian or Alaska Native 0 0.0 2 0.5  
 Asian 0 0.0 11 2.8  
 Black or African American 7 11.7 38 9.6  
 White 50 83.3 334 84.1  
 Unknown 3 5.0 12 3.0  
Smoking History      < 0.001
 Never Smoker 2 3.3 99 24.9  
 Current Smoker 32 53.3 129 32.5  
 Former Smoker 25 41.7 158 39.8  
 Blank 1 1.7 11 2.8  
Alcohol Use      0.37
 No 15 25.0 134 33.8  
 Yes 44 73.3 254 64.0  
 Unknown 1 1.7 9 2.3  
Stagea      0.15
 Stage I, II 9 15.0 97 24.4  
 Stage III 19 31.7 81 20.4  
 Stage IV 31 51.7 207 52.1  
 Unknown 1 1.7 12 3.0  
  1. *p-value is calculated from chi-square test for categorical variables or Wilcoxon rank-sum test for age (continuous)
  2. aStages assigned using AJCC 7th edition (76%), 6th edition (21%), 5th edition (2%), and 4th edition (< 1%)