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Fig. 9 | Cancers of the Head & Neck

Fig. 9

From: NSD1 mutations by HPV status in head and neck cancer: differences in survival and response to DNA-damaging agents

Fig. 9

NSD1 knockdown increases cell sensitivity to DNA crosslinking agents. (a) Short-term viability assay using CellTiterGlo (Promega) of FaDu cells expressing control (black) or NSD1 (red, NSD1sh) shRNA, treated or not with carboplatin or cisplatin (as indicated) for 72 h. Short-term viability of FaDu (b), HaCat (c), or SCC35 (d) cells expressing control (black) or another NSD1 (red, NSD1sh a) shRNA, treated or not with cisplatin. (e) Long-term clonogenic survival of FaDu (top) and HaCat (bottom) cells expressing control (black) or NSD1 (red) shRNA, treated or not with carboplatin. * Indicates P < 0.05

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Cancers of the Head & Neck

ISSN: 2059-7347

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