Fig. 2From: NSD1 mutations by HPV status in head and neck cancer: differences in survival and response to DNA-damaging agentsNSD1 mutations in HPV(−) and HPV(+) HNSCC are inactivating mutations. (a) Schematic representation of missense point (green) and truncating (black) mutations in NSD1 found in HPV-negative HNSCC; functional NSD1 domains are indicated in colors. Adapted from www.cBioPortal.org [41, 42]. b Pathogenicity of HPV(−) NSD1 missense point mutations. (c) Pathogenicity of HPV(+) NSD1 mutations. Pathogenicity determined with UMD-predictor [21]Back to article page