Table 2 Major differences between cervical cancer and HPV-associated OPSCC
| Â | OPSCC | Cervical Cancer |
|---|---|---|
Incidence | Incidence increasing | Incidence decreasing |
Prevalence | Increased in higher-income countries | Increased in lower-income countries |
Sex | > 70% male | 100% female |
Etiology | Tobacco and alcohol remain important causes, along with HPV | Virtually all are caused by HPV |
HPV genotype | > 95% HPV16 HPV18 rare | 50% HPV16 20% HPV18 |
Premalignant lesions | Unknown | CIN1–3 |
Screening tests available | No | Yes |
5-year survival rate | > 75% | < 70% |
TRAF3/CYLD mutations | Approximately 30% | Rare |
Treatment sensitivity to chemotherapy and radiation | High | Moderate |