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Table 2 Major differences between cervical cancer and HPV-associated OPSCC

From: HPV-driven oropharyngeal cancer: current knowledge of molecular biology and mechanisms of carcinogenesis

  OPSCC Cervical Cancer
Incidence Incidence increasing Incidence decreasing
Prevalence Increased in higher-income countries Increased in lower-income countries
Sex > 70% male 100% female
Etiology Tobacco and alcohol remain important causes, along with HPV Virtually all are caused by HPV
HPV genotype > 95% HPV16
HPV18 rare
50% HPV16
20% HPV18
Premalignant lesions Unknown CIN1–3
Screening tests available No Yes
5-year survival rate > 75% < 70%
TRAF3/CYLD mutations Approximately 30% Rare
Treatment sensitivity to chemotherapy and radiation High Moderate