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Table 4 Cox proportional hazards regression analysis for patients with oral cavity squamous cell carcinoma

From: Sex differences in patients with high risk HPV-associated and HPV negative oropharyngeal and oral cavity squamous cell carcinomas

  Oral Cavity HPV-associated Oral Cavity HPV -
HR (95% CI) P HR (95% CI) P
Mean age 1.02 (1.00–1.04) 0.010 1.02 (1.02–1.02) < 0.001
Ethnicity
 White 1.00   1.00  
 Black 1.88 (1.14–3.11) 0.013 0.93 (0.79–1.09) 0.41
 American Indian/Eskimo a   1.18 (0.52–2.64) 0.68
 Asian/Pacific Islander 1.60 (0.64–4.00) 0.312 0.93 (0.71–1.22) 0.63
 Other 0.65 (0.09–4.78) 0.678 0.54 (0.30–0.99) 0.05
Sex
Men 1.00   1.00  
Women 0.71 (0.50–0.99) 0.048 0.87 (0.78–0.95) 0.004
AJCC Clinical Staging
 T Staging     
  T0 1.00   1.00  
  T1 0.36 (0.07–1.65) 0.189 0.45 (0.14–1.43) 0.18
  T2 0.61 (0.13–2.80) 0.529 0.79 (0.25–2.49) 0.70
  T3 0.90 (0.19–4.21) 0.903 1.07 (0.34–3.38) 0.90
  T4 1.33 (0.29–5.98) 0.707 1.19 (0.37–3.73) 0.76
  TX 0.67 (0.11–4.00) 0.666 1.36 (0.39–4.70) 0.63
  N Staging     
  N0 1.00   1.00  
  N1 1.07 (0.70–1.63) 0.743 1.54 (1.34–1.77) < 0.001
  N2 1.08 (0.75–1.55) 0.651 1.72 (1.52–1.94) < 0.001
  N3 0.88 (0.26–2.93) 0.836 2.12 (1.49–3.03) < 0.001
  NX 1.30 (0.17–9.88) 0.795 1.19 (0.75–1.89) 0.45
Insurance Status
 Not Insured 1.00   1.00  
 Private Insurance/Managed Care 0.74 (0.42–1.32) 0.319 0.81 (0.65–1.00) 0.06
 Medicaid 1.82 (0.96–3.43) 0.064 1.27 (1.00–1.60) 0.043
 Medicare 1.32 (0.72–2.41) 0.355 1.04 (0.83–1.30) 0.72
 Other Government 0.83 (0.31–2.19) 0.713 1.17 (0.78–1.76) 0.44
Median Income Quartiles 2008–2012
  < $38,000 1.00   1.00  
 $38,000–$47,999 1.38 (0.88–2.17) 0.160 0.84 (0.73–0.96) 0.02
 $48,000–$62,999 1.49 (0.96–2.33) 0.075 0.90 (0.79–1.03) 0.14
 $63,000 + 1.37 (0.87–2.16) 0.169 0.77 (0.67–0.88) < 0.001
Treatment Group
 No treatment 1.00   1.00  
 Radiation only 0.56 (0.25–1.23) 0.151 0.49 (0.37–0.63) < 0.001
 Radiation and Chemo 0.42 (0.22–0.82) 0.011 0.44 (0.35–0.55) < 0.001
 Surgery and Radiation 0.23 (0.10–0.50) < 0.001 0.33 (0.26–0.43) < 0.001
 Surgery, Chemotherapy and Radiation 0.59 (0.30–1.15) 0.127 0.42 (0.33–0.53) < 0.001
 Surgery only 0.48 (0.24–0.94) 0.033 0.37 (0.29–0.45) < 0.001
 Chemotherapy Only 1.18 (0.49–2.82) 0.710 0.84 (0.61–1.16) 0.31
  1. aInsufficient sample size