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Table 3 Cox proportional hazards regression analysis for patients with oropharyngeal squamous cell carcinoma

From: Sex differences in patients with high risk HPV-associated and HPV negative oropharyngeal and oral cavity squamous cell carcinomas

  Oropharynx HPV-associated Oropharynx HPV -
HR (95% CI) P HR (95% CI) P
Mean age 1.02 (1.01–1.03) < 0.001 1.01 (1.00–1.02) < 0.001
Ethnicity
 White 1.00   1.00  
 Black 0.86 (0.67–1.10) 0.25 1.14 (1.01–1.30) 0.03
 American Indian/Eskimo 0.61 (0.15–2.47) 0.49 0.22 (0.03–1.58) 0.13
 Asian/Pacific Islander 0.52 (0.24–1.10) 0.09 0.75 (0.50–1.14) 0.19
 Other 0.63 (0.15–2.52) 0.51 1.29 (0.67–2.49) 0.44
Sex
Men 1.00   1.00  
Women 0.93 (0.79–1.09) 0.412 1.15 (1.04–1.28) 0.004
Charlson/Deyo Score
 0 1.0   1.0  
 1 1.42 (1.23–1.65) < 0.001 1.31 (1.17–1.46) < 0.001
 2 1.97 (1.56–2.48) < 0.001 1.49 (1.25–1.77) < 0.001
AJCC Clinical Staging     
 T Staging
  T0 1.00   1.00  
  T1 2.61 (0.64–10.5) 0.18 1.31 (0.32–5.30) 0.70
  T2 4.24 (1.05–17.0) 0.04 1.93 (0.48–7.79) 0.35
  T3 6.47 (1.60–26.1) 0.01 3.26 (0.81–13.1) 0.10
  T4 9.92 (2.45–40.0) 0.00 4.35 (1.08–17.5) 0.04
  TX 3.93 (0.93–16.4) 0.06 2.65 (0.64–10.9) 0.18
N Staging
  N0 1.00   1.00  
  N1 0.81 (0.64–1.01) 0.07 0.95 (0.82–1.10) 0.53
  N2 1.14 (0.95–1.37) 0.14 1.10 (0.98–1.24) 0.09
  N3 2.06 (1.58–2.67) < 0.001 1.76 (1.45–2.15) < 0.001
  NX 0.73 (0.29–1.83) 0.51 1.47 (0.91–2.36) 0.11
Primary Site
 Base of Tongue 1.00   1.00  
 Tonsil 1.03 (0.91–1.16) 0.63 0.87 (0.79–0.96) 0.01
 Other OP 1.48 (1.21–1.81) < 0.001 1.15 (1.02–1.30) 0.02
Insurance Status
 Not Insured 1.00   1.00  
 Private Insurance/Managed Care 0.53 (0.41–0.68) < 0.001 0.61 (0.51–0.72) < 0.001
 Medicaid 1.04 (0.78–1.38) 0.77 1.11 (0.93–1.34) 0.23
 Medicare 0.99 (0.76–1.30) 0.98 0.94 (0.78–1.13) 0.55
 Other Government 0.96 (0.63–1.46) 0.85 0.96 (0.67–1.36) 0.83
Median Income Quartiles 2008–2012
  < $38,000 1.00   1.00  
 $38,000–$47,999 0.89 (0.75–1.06) 0.21 0.9 (0.79–1.02) 0.11
 $48,000–$62,999 0.78 (0.65–0.93) 0.01 0.83 (0.73–0.94) 0.01
 $63,000 + 0.65 (0.54–0.77) < 0.001 0.73 (0.64–0.83) < 0.001
Treatment Group
 No treatment 1.00   1.00  
 Radiation only 0.34 (0.24–0.48) < 0.001 0.44 (0.35–0.54) < 0.001
 Radiation and Chemo 0.22 (0.16–0.29) < 0.001 0.27 (0.23–0.33) < 0.001
 Surgery and Radiation 0.16 (0.10–0.24) < 0.001 0.20 (0.14–0.28) < 0.001
 Surgery, Chemotherapy and Radiation 0.21 (0.15–0.29) < 0.001 0.29 (0.23–0.35) < 0.001
 Surgery only 0.21 (0.14–0.32) < 0.001 0.37 (0.29–0.47) < 0.001
 Chemotherapy Only 1.08 (0.76–1.54) 0.64 0.94 (0.76–1.18) 0.64