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Table 3 Cox proportional hazards regression analysis for patients with oropharyngeal squamous cell carcinoma

From: Sex differences in patients with high risk HPV-associated and HPV negative oropharyngeal and oral cavity squamous cell carcinomas

 

Oropharynx HPV-associated

Oropharynx HPV -

HR (95% CI)

P

HR (95% CI)

P

Mean age

1.02 (1.01–1.03)

< 0.001

1.01 (1.00–1.02)

< 0.001

Ethnicity

 White

1.00

 

1.00

 

 Black

0.86 (0.67–1.10)

0.25

1.14 (1.01–1.30)

0.03

 American Indian/Eskimo

0.61 (0.15–2.47)

0.49

0.22 (0.03–1.58)

0.13

 Asian/Pacific Islander

0.52 (0.24–1.10)

0.09

0.75 (0.50–1.14)

0.19

 Other

0.63 (0.15–2.52)

0.51

1.29 (0.67–2.49)

0.44

Sex

Men

1.00

 

1.00

 

Women

0.93 (0.79–1.09)

0.412

1.15 (1.04–1.28)

0.004

Charlson/Deyo Score

 0

1.0

 

1.0

 

 1

1.42 (1.23–1.65)

< 0.001

1.31 (1.17–1.46)

< 0.001

 2

1.97 (1.56–2.48)

< 0.001

1.49 (1.25–1.77)

< 0.001

AJCC Clinical Staging

    

 T Staging

  T0

1.00

 

1.00

 

  T1

2.61 (0.64–10.5)

0.18

1.31 (0.32–5.30)

0.70

  T2

4.24 (1.05–17.0)

0.04

1.93 (0.48–7.79)

0.35

  T3

6.47 (1.60–26.1)

0.01

3.26 (0.81–13.1)

0.10

  T4

9.92 (2.45–40.0)

0.00

4.35 (1.08–17.5)

0.04

  TX

3.93 (0.93–16.4)

0.06

2.65 (0.64–10.9)

0.18

N Staging

  N0

1.00

 

1.00

 

  N1

0.81 (0.64–1.01)

0.07

0.95 (0.82–1.10)

0.53

  N2

1.14 (0.95–1.37)

0.14

1.10 (0.98–1.24)

0.09

  N3

2.06 (1.58–2.67)

< 0.001

1.76 (1.45–2.15)

< 0.001

  NX

0.73 (0.29–1.83)

0.51

1.47 (0.91–2.36)

0.11

Primary Site

 Base of Tongue

1.00

 

1.00

 

 Tonsil

1.03 (0.91–1.16)

0.63

0.87 (0.79–0.96)

0.01

 Other OP

1.48 (1.21–1.81)

< 0.001

1.15 (1.02–1.30)

0.02

Insurance Status

 Not Insured

1.00

 

1.00

 

 Private Insurance/Managed Care

0.53 (0.41–0.68)

< 0.001

0.61 (0.51–0.72)

< 0.001

 Medicaid

1.04 (0.78–1.38)

0.77

1.11 (0.93–1.34)

0.23

 Medicare

0.99 (0.76–1.30)

0.98

0.94 (0.78–1.13)

0.55

 Other Government

0.96 (0.63–1.46)

0.85

0.96 (0.67–1.36)

0.83

Median Income Quartiles 2008–2012

  < $38,000

1.00

 

1.00

 

 $38,000–$47,999

0.89 (0.75–1.06)

0.21

0.9 (0.79–1.02)

0.11

 $48,000–$62,999

0.78 (0.65–0.93)

0.01

0.83 (0.73–0.94)

0.01

 $63,000 +

0.65 (0.54–0.77)

< 0.001

0.73 (0.64–0.83)

< 0.001

Treatment Group

 No treatment

1.00

 

1.00

 

 Radiation only

0.34 (0.24–0.48)

< 0.001

0.44 (0.35–0.54)

< 0.001

 Radiation and Chemo

0.22 (0.16–0.29)

< 0.001

0.27 (0.23–0.33)

< 0.001

 Surgery and Radiation

0.16 (0.10–0.24)

< 0.001

0.20 (0.14–0.28)

< 0.001

 Surgery, Chemotherapy and Radiation

0.21 (0.15–0.29)

< 0.001

0.29 (0.23–0.35)

< 0.001

 Surgery only

0.21 (0.14–0.32)

< 0.001

0.37 (0.29–0.47)

< 0.001

 Chemotherapy Only

1.08 (0.76–1.54)

0.64

0.94 (0.76–1.18)

0.64