From: Predictors of circulating INTERLEUKIN-6 levels in head and neck cancer patients
Factors | Categories | Median IL-6 (ng/L) (IQR) | Crude β (SE) | P-value |
---|---|---|---|---|
Age (years) | ≤ 50 | 2.4 (1.0–3.7) | Reference |  |
>  50 ≤ 60 | 2.9 (2.0–3.9) | 0.15 (0.11) |  | |
>  60 ≤ 70 | 3.2 (2.4–4.4) | 0.34 (0.11) |  | |
>  70 | 3.5 (2.6–5.1) | 0.48 (0.11) | <  0.0001 | |
Sex | Female | 3.0 (2.2–3.9) | Reference |  |
Male | 3.1 (2.2–4.6) | 0.15 (0.07) | 0.04 | |
Current body mass index (kg/m2) | <  18.5 | 3.5 (2.5–5.1) | 0.13 (0.17) |  |
≥ 18.5 < 30 | 2.9 (2.1–4.1) | Reference |  | |
≥ 30 | 3.8 (2.7–4.9) | 0.22 (0.08) | 0.02 | |
Body mass index at 20 years (kg/m2) | <  18.5 | 3.0 (2.0–4.9) | −0.06 (0.11) |  |
≥ 18.5 < 30 | 3.1 (2.2–4.4) | Reference |  | |
≥ 30 | 4.1 (2.7–7.0) | 0.43 (0.17) | 0.04 | |
Marital status | Not married | 3.3 (2.5–4.6) | Reference |  |
Married | 3.0 (2.1–4.4) | −0.16 (0.07) | 0.02 | |
Household income (per year) | < $40,000 | 3.3 (2.3–4.6) | Reference |  |
≥ $40,000 | 2.7 (2.0–3.7) | −0.22 (0.07) | 0.02 | |
Karnofsky Performance Status (%) | 90–100 | 3.0 (2.2–4.3) | Reference |  |
60–80 | 4.9 (2.9–5.8) | 0.46 (0.11) | <  0.0001 | |
Charlson Comorbidity Index | 0 | 2.9 (2.1–3.9) | Reference |  |
1 | 3.4 (2.1–5.1) | 0.24 (0.07) |  | |
≥ 2 | 3.7 (2.8–5.2) | 0.38 (0.09) | <  0.0001 | |
Diabetes | No | 3.0 (2.2–4.4) | Reference |  |
Yes | 3.6 (2.8–5.0) | 0.22 (0.12) | 0.06 | |
Glottic cancer | No | 3.5 (2.5–5.0) | Reference |  |
Yes | 2.9 (2.1–4.1) | −0.22 (0.06) | 0.0004 | |
TNM clinical stage | I | 2.9 (2.1–4.2) | Reference |  |
II | 3.4 (2.4–4.9) | 0.17 (0.06) | 0.007 | |
Tobacco consumption (all tobacco products) | Never | 2.2 (1.0–3.3) | Reference |  |
Former | 3.0 (2.2–4.4) | 0.48 (0.14) |  | |
Current | 3.5 (2.4–5.1) | 0.57 (0.15) | 0.0008 | |
History of alcohol abuse | No | 3.0 (2.2–4.3) | Reference |  |
Yes | 3.6 (2.5–5.3) | 0.18 (0.08) | 0.03 | |
Alcohol consumption during the preceding year (g/d) | 0 | 3.4 (2.3–4.6) | Reference |  |
≤ 2.32 | 3.0 (2.1–4.3) | −0.03 (0.09) | 0.31 | |
>  2.32 ≤ 12.48 | 2.9 (2.2–4.2) | −0.13 (0.09) |  | |
> 12.48 | 3.1 (2.4–5.0) | 0.02 (0.09) |  | |
Alcohol consumption during the past 10 years (g/d) | ≤ 0.39 | 3.3 (2.1–4.3) | Reference |  |
>  0.39 ≤ 10.49 | 3.1 (2.2–4.4) | −0.05 (0.09) |  | |
>  10.49 ≤ 42.88 | 2.8 (2.1–4.1) | −0.08 (0.09) |  | |
>  42.88 | 3.3 (2.5–5.1) | 0.04 (0.09) | 0.50 | |
Sleep disturbance | Not at all | 3.0 (2.1–4.4) | Reference |  |
A little | 3.0 (2.2–4.0) | −0.004 (0.07) |  | |
Quite a bit | 3.5 (2.5–4.9) | 0.16 (0.10) |  | |
Very much | 3.1 (2.5–5.0) | 0.17 (0.11) | 0.20 |