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Table 1 Case reports of synchronous SCC of aerodigestive tract and lymphoma treated with upfront R-CHOP chemotherapy

From: Response to R-CHOP in HPV-related squamous cell carcinoma of base of tongue: a case report

Study Patient characteristics Index primary Synchronous secondary primary Treatment regimen Response Remarks
Morita et al., 2009 [22] 75-year-old female DLBCL (lower lip) SCC (buccal mucosa) 6 cycles of R-THP-COP Complete response for DLBCL, partial response for SCC SCC was subsequently treated with tegafur, gimeracil and oteracil potassium with partial response
Oikonomou et al., 2013 [24] 72-year-old male, 20 pack-yr smoking hx BALT Lymphoma (LLL) low-differentiated lung SCC (RML) 3 cycles of R-CHOP Significant reduction in size of lymphoma and stability of the lung SCC 9-month follow-up CT revealed progression of the lung cancer with distant metastatic disease
Fujii et al., 2014 [23] 68-year-old female DLBCL (Left cervical LNs) Lung SCC (RUL and hilar and mediastinal LNs) 3 cycles of R-CHOP Complete response for DLBCL; pulmonary SCC and right hilar LN stable/increased Radical surgery performed after 3 cycles of R-CHOP to resect lung SCC
  1. DLBCL diffuse large B-cell lymphoma, SCC squamous cell carcinoma, BALT bronchial-associated lymphoid tissue, LLL left lower lobe, RML right middle lobe, RUL right upper lobe, LN lymph node, R-THP-COP rituximab, pirarubicin, cyclophosphamide, vincristine, and prednisolone