Table 1 Case reports of synchronous SCC of aerodigestive tract and lymphoma treated with upfront R-CHOP chemotherapy
From: Response to R-CHOP in HPV-related squamous cell carcinoma of base of tongue: a case report
Study | Patient characteristics | Index primary | Synchronous secondary primary | Treatment regimen | Response | Remarks |
|---|---|---|---|---|---|---|
Morita et al., 2009 [22] | 75-year-old female | DLBCL (lower lip) | SCC (buccal mucosa) | 6 cycles of R-THP-COP | Complete response for DLBCL, partial response for SCC | SCC was subsequently treated with tegafur, gimeracil and oteracil potassium with partial response |
Oikonomou et al., 2013 [24] | 72-year-old male, 20 pack-yr smoking hx | BALT Lymphoma (LLL) | low-differentiated lung SCC (RML) | 3 cycles of R-CHOP | Significant reduction in size of lymphoma and stability of the lung SCC | 9-month follow-up CT revealed progression of the lung cancer with distant metastatic disease |
Fujii et al., 2014 [23] | 68-year-old female | DLBCL (Left cervical LNs) | Lung SCC (RUL and hilar and mediastinal LNs) | 3 cycles of R-CHOP | Complete response for DLBCL; pulmonary SCC and right hilar LN stable/increased | Radical surgery performed after 3 cycles of R-CHOP to resect lung SCC |