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Table 1 Baseline patient, disease, and treatment characteristics

From: Outcomes for patients with head and neck squamous cell carcinoma presenting with N3 nodal disease

 

CRT (n = 20)

RT (n = 8)

Surgery (n = 8)

All (n = 36)

p-value

Age

    

0.51

 Median

58.5

60.5

60

59

 

 (range)

(43–70)

(44–78)

(48–78)

(43–78)

 

Sex

    

0.49

 Male

18 (90.0%)

6 (75.0%)

6 (75.0%)

30 (83.3%)

 

Race

    

0.86

 Black

6 (30.0%)

3 (37.5%)

2 (25.0%)

11 (30.6%)

 

 White

14 (70.0%)

5 (62.5%)

6 (75.0%)

25 (69.4%)

 

p16

    

0.64

 Negative

2 (10.0%)

1 (12.5%)

2 (25.0%)

5 (13.9%)

 

 Positive

7 (35.0%)

1 (12.5%)

2 (25.0%)

10 (27.8%)

 

 Unknown

11 (55.0%)

6 (75.0%)

4 (50.0%)

21 (58.3%)

 

Planned neck dissection of N3 neck

    

0.27

 Yes

11 (55.0%)

5 (62.5%)

7 (87.5%)

23 (63.9%)

 

Tumor Site

    

0.42

 Hypopharynx

1 (5.0%)

2 (25.0%)

1 (12.5%)

4 (11.1%)

 

 Larynx

3 (15.0%)

0 (0.0%)

0 (0.0%)

3 (8.3%)

 

 Oral Cavity

0 (0.0%)

0 (0.0%)

1 (12.5%)

1 (2.8%)

 

 Oropharynx

14 (70.0%)

5 (62.5%)

5 (62.5%)

24 (66.7%)

 

 Unknown

2 (10.0%)

1 (12.5%)

1 (12.5%)

4 (11.1%)

 

T-Stage

    

0.94

 T0

2 (10.0%)

1 (12.5%)

1 (12.5%)

4 (11.1%)

 

 T1

3 (15.0%)

2 (25.0%)

3 (37.5%)

8 (22.2%)

 

 T2

5 (25.0%)

2 (25.0%)

1 (12.5%)

8 (22.2%)

 

 T3

6 (30.0%)

1 (12.5%)

0 (0.0%)

9 (25.0%)

 

 T4

4 (20.0%)

2 (25.0%)

1 (12.5%)

7 (19.4%)

 

RT Type

    

< 0.01

 IMRT

13 (65.0%)

0 (0.0%)

6 (75.0%)

19 (52.8%)

 

 Non-IMRT

7 (35.0%)

8 (100.0%)

2 (25.0%)

17 (47.2%)

 

Fraction Size

    

< 0.01

 Median

2.11

1.67

2.0

2.0

 

 (range)

(1.4–2.2)

(1.2–2.0)

(1.2–2.1)

(1.2–2.2)

 

RT Total Dose

    

0.18

 Median

7000 cGy

7010 cGy

6800 cGy

7000 cGy

 

 (range)

(6572–7320)

(6700–7460)

(6000–7440)

(6000–7460)

 

Nodal Volume

    

0.88

 Median

40.3

37.8

48.8

42.7

 

 (range)

(17.3–194.8)

(15.9–81.2)

(23.1–76.0)

(15.9–194.8)

 
  1. Abbreviations: RT radiotherapy, CRT chemoradiotherapy, IMRT intensity modulated Radiotherapy