Table 2 Inclusion criteria for select randomized adjuvant treatment trials comparing chemoradiation versus radiation alone
From: De-intensification of adjuvant therapy in human papillomavirus-associated oropharyngeal cancer
Trial | Inclusion criteria |
|---|---|
EORTC 22931 [23] | Sites: oral cavity, oropharynx, larynx, or hypopharynx |
1 of the following: | |
 • pT3-4 N0-3 except for T3N0 of the larynx with negative resection margins  • pT1-2 N2-3  • pT1-2 N0-1 and positive margins, PNI, or vascular embolism (lymphovascular invasion)  • oral cavity or oropharyngeal primaries with level IV or V lymph node involvement | |
RTOG 9501 [22] | Sites: oral cavity, oropharynx, larynx, or hypopharynx Status post complete macroscopic resection |
1 of the following | |
 • two or more metastatic regional lymph nodes  • extracapsular extension  • microscopically involved mucosal margins of resection |