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Table 2 Inclusion criteria for select randomized adjuvant treatment trials comparing chemoradiation versus radiation alone

From: De-intensification of adjuvant therapy in human papillomavirus-associated oropharyngeal cancer

Trial Inclusion criteria
EORTC 22931 [23] Sites: oral cavity, oropharynx, larynx, or hypopharynx
1 of the following:
 • pT3-4 N0-3 except for T3N0 of the larynx with negative resection margins
 • pT1-2 N2-3
 • pT1-2 N0-1 and positive margins, PNI, or vascular embolism (lymphovascular invasion)
 • oral cavity or oropharyngeal primaries with level IV or V lymph node involvement
RTOG 9501 [22] Sites: oral cavity, oropharynx, larynx, or hypopharynx
Status post complete macroscopic resection
1 of the following
 • two or more metastatic regional lymph nodes
 • extracapsular extension
 • microscopically involved mucosal margins of resection