Skip to main content

Table 1 Select prospective trials that demonstrated improved outcomes for HPV-associated disease on unplanned retrospective subgroup analysis

From: De-intensification of adjuvant therapy in human papillomavirus-associated oropharyngeal cancer

Trial Comparison arms Finding (HPV+ improved outcomes)
RTOG 0129 [44] 70 Gy over 7 weeks vs 72 Gy over 6 weeks. Both arms included concurrent cisplatin 8-years OS
70.9% vs. 30.2%
RTOG 0522 [45] Concurrent radiation with cisplatin +/- cetuximab 3-years OS
85.6% vs. 60.1%
ECOG 2399 [46] Phase II trial: 2 cycles of induction paclitaxel/carboplatin followed by radiation with concurrent paclitaxel 2-years OS
95% vs. 62%
TROG 02.02 [47] Radiation with concurrent cisplatin vs. radiation with concurrent cisplatin and tirapazamine 2-years OS
91% vs. 74%
TAX 324 [48] Induction docetaxel/cisplatin/fluorouracil followed by radiation with concurrent carboplatin vs. induction cisplatin/fluorouracil followed by radiation with concurrent carboplatin 5-years OS
82% vs. 35%