Table 4 Cox proportional hazards regression analysis for patients with oral cavity squamous cell carcinoma
Oral Cavity HPV-associated | Oral Cavity HPV - | |||
|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | |
Mean age | 1.02 (1.00–1.04) | 0.010 | 1.02 (1.02–1.02) | < 0.001 |
Ethnicity | ||||
White | 1.00 | 1.00 | ||
Black | 1.88 (1.14–3.11) | 0.013 | 0.93 (0.79–1.09) | 0.41 |
American Indian/Eskimo | a | 1.18 (0.52–2.64) | 0.68 | |
Asian/Pacific Islander | 1.60 (0.64–4.00) | 0.312 | 0.93 (0.71–1.22) | 0.63 |
Other | 0.65 (0.09–4.78) | 0.678 | 0.54 (0.30–0.99) | 0.05 |
Sex | ||||
Men | 1.00 | 1.00 | ||
Women | 0.71 (0.50–0.99) | 0.048 | 0.87 (0.78–0.95) | 0.004 |
AJCC Clinical Staging | ||||
T Staging | ||||
T0 | 1.00 | 1.00 | ||
T1 | 0.36 (0.07–1.65) | 0.189 | 0.45 (0.14–1.43) | 0.18 |
T2 | 0.61 (0.13–2.80) | 0.529 | 0.79 (0.25–2.49) | 0.70 |
T3 | 0.90 (0.19–4.21) | 0.903 | 1.07 (0.34–3.38) | 0.90 |
T4 | 1.33 (0.29–5.98) | 0.707 | 1.19 (0.37–3.73) | 0.76 |
TX | 0.67 (0.11–4.00) | 0.666 | 1.36 (0.39–4.70) | 0.63 |
N Staging | ||||
N0 | 1.00 | 1.00 | ||
N1 | 1.07 (0.70–1.63) | 0.743 | 1.54 (1.34–1.77) | < 0.001 |
N2 | 1.08 (0.75–1.55) | 0.651 | 1.72 (1.52–1.94) | < 0.001 |
N3 | 0.88 (0.26–2.93) | 0.836 | 2.12 (1.49–3.03) | < 0.001 |
NX | 1.30 (0.17–9.88) | 0.795 | 1.19 (0.75–1.89) | 0.45 |
Insurance Status | ||||
Not Insured | 1.00 | 1.00 | ||
Private Insurance/Managed Care | 0.74 (0.42–1.32) | 0.319 | 0.81 (0.65–1.00) | 0.06 |
Medicaid | 1.82 (0.96–3.43) | 0.064 | 1.27 (1.00–1.60) | 0.043 |
Medicare | 1.32 (0.72–2.41) | 0.355 | 1.04 (0.83–1.30) | 0.72 |
Other Government | 0.83 (0.31–2.19) | 0.713 | 1.17 (0.78–1.76) | 0.44 |
Median Income Quartiles 2008–2012 | ||||
< $38,000 | 1.00 | 1.00 | ||
$38,000–$47,999 | 1.38 (0.88–2.17) | 0.160 | 0.84 (0.73–0.96) | 0.02 |
$48,000–$62,999 | 1.49 (0.96–2.33) | 0.075 | 0.90 (0.79–1.03) | 0.14 |
$63,000 + | 1.37 (0.87–2.16) | 0.169 | 0.77 (0.67–0.88) | < 0.001 |
Treatment Group | ||||
No treatment | 1.00 | 1.00 | ||
Radiation only | 0.56 (0.25–1.23) | 0.151 | 0.49 (0.37–0.63) | < 0.001 |
Radiation and Chemo | 0.42 (0.22–0.82) | 0.011 | 0.44 (0.35–0.55) | < 0.001 |
Surgery and Radiation | 0.23 (0.10–0.50) | < 0.001 | 0.33 (0.26–0.43) | < 0.001 |
Surgery, Chemotherapy and Radiation | 0.59 (0.30–1.15) | 0.127 | 0.42 (0.33–0.53) | < 0.001 |
Surgery only | 0.48 (0.24–0.94) | 0.033 | 0.37 (0.29–0.45) | < 0.001 |
Chemotherapy Only | 1.18 (0.49–2.82) | 0.710 | 0.84 (0.61–1.16) | 0.31 |